Serum uric acid is associated with damage in patients with systemic lupus erythematosus
Identifieur interne : 000055 ( an2020/Analysis ); précédent : 000054; suivant : 000056Serum uric acid is associated with damage in patients with systemic lupus erythematosus
Auteurs : Claudia Elera-Fitzcarrald [Pérou] ; Cristina Reátegui-Sokolova [Pérou] ; Rocio Violeta Gamboa-Cardenas [Pérou] ; Mariela Medina [Pérou] ; Francisco Zevallos [Pérou] ; Victor Román Pimentel-Quiroz [Pérou] ; Jorge Mariano Cucho-Venegas [Pérou] ; José Alfaro-Lozano [Pérou] ; Zoila Rodriguez-Bellido [Pérou] ; Cesar Augusto Pastor-Asurza [Pérou] ; Risto Alfredo Perich-Campos [Pérou] ; Graciela S. Alarc N [États-Unis, Pérou] ; Manuel Francisco Ugarte-Gil [Pérou]Source :
- Lupus Science & Medicine [ 2053-8790 ] ; 2020.
Abstract
Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.
To determine whether serum uric acid levels are associated with new damage in patients with SLE.
This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.
We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).
Higher serum uric acid levels are associated with global damage in patients with SLE.
Url:
DOI: 10.1136/lupus-2019-000366
PubMed: 32153795
PubMed Central: 7046960
Affiliations:
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EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Reategui Sokolova, Cristina" sort="Reategui Sokolova, Cristina" uniqKey="Reategui Sokolova C" first="Cristina" last="Reátegui-Sokolova">Cristina Reátegui-Sokolova</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud</institution>,<institution>Universidad San Ignancio de Loyola</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gamboa Cardenas, Rocio Violeta" sort="Gamboa Cardenas, Rocio Violeta" uniqKey="Gamboa Cardenas R" first="Rocio Violeta" last="Gamboa-Cardenas">Rocio Violeta Gamboa-Cardenas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Medina, Mariela" sort="Medina, Mariela" uniqKey="Medina M" first="Mariela" last="Medina">Mariela Medina</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zevallos, Francisco" sort="Zevallos, Francisco" uniqKey="Zevallos F" first="Francisco" last="Zevallos">Francisco Zevallos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pimentel Quiroz, Victor Roman" sort="Pimentel Quiroz, Victor Roman" uniqKey="Pimentel Quiroz V" first="Victor Román" last="Pimentel-Quiroz">Victor Román Pimentel-Quiroz</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cucho Venegas, Jorge Mariano" sort="Cucho Venegas, Jorge Mariano" uniqKey="Cucho Venegas J" first="Jorge Mariano" last="Cucho-Venegas">Jorge Mariano Cucho-Venegas</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alfaro Lozano, Jose" sort="Alfaro Lozano, Jose" uniqKey="Alfaro Lozano J" first="José" last="Alfaro-Lozano">José Alfaro-Lozano</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez Bellido, Zoila" sort="Rodriguez Bellido, Zoila" uniqKey="Rodriguez Bellido Z" first="Zoila" last="Rodriguez-Bellido">Zoila Rodriguez-Bellido</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pastor Asurza, Cesar Augusto" sort="Pastor Asurza, Cesar Augusto" uniqKey="Pastor Asurza C" first="Cesar Augusto" last="Pastor-Asurza">Cesar Augusto Pastor-Asurza</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Perich Campos, Risto Alfredo" sort="Perich Campos, Risto Alfredo" uniqKey="Perich Campos R" first="Risto Alfredo" last="Perich-Campos">Risto Alfredo Perich-Campos</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Universidad Nacional Mayor de San Marcos</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution content-type="department">Department of Medicine, Division of Clinical Immunology and Rheumatology</institution>,<institution>School of Medicine, The University of Alabama</institution>,<addr-line content-type="city">Birmingham</addr-line>,<addr-line content-type="state">Alabama</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution content-type="department">Department of Medicine</institution>,<institution>Universidad Peruana Cayetana Heredia</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ugarte Gil, Manuel Francisco" sort="Ugarte Gil, Manuel Francisco" uniqKey="Ugarte Gil M" first="Manuel Francisco" last="Ugarte-Gil">Manuel Francisco Ugarte-Gil</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">School of Medicine</institution>,<institution>Universidad Científica del Sur</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Rheumatology</institution>,<institution>Hospital Nacional Guillermo Almenara Irigoyen, EsSalud</institution>,<addr-line content-type="city">Lima</addr-line>,<country>Peru</country></nlm:aff><country xml:lang="fr">Pérou</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Lupus Science & Medicine</title><idno type="eISSN">2053-8790</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Serum uric acid levels have been reported as predictors of cardiovascular, pulmonary, neurological and renal morbidity in patients with SLE. However, their role in cumulative global damage in these patients has not yet been determined.</p></sec><sec><title>Objective</title><p>To determine whether serum uric acid levels are associated with new damage in patients with SLE.</p></sec><sec><title>Methods</title><p>This is a longitudinal study of patients with SLE from the Almenara Lupus Cohort, which began in 2012. At each visit, demographic and clinical characteristics were evaluated, such as activity (Systemic Lupus Erythematosus Disease Activity Index-2K or SLEDAI-2K) and cumulative damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index or SDI). Treatment (glucocorticoids, immunosuppressive drugs and antimalarials) was also recorded. Univariable and multivariable Cox regression models were used to determine the impact of serum uric acid levels on the risk of new damage.</p></sec><sec><title>Results</title><p>We evaluated 237 patients, with a mean age (SD) at diagnosis of 35.9 (13.1) years; 220 patients (92.8%) were women, and the duration of the disease was 7.3 (6.6) years. The mean SLEDAI-2K and SDI scores were 5.1 (4.2) and 0.9 (1.3), respectively. Serum uric acid level was 4.5 (1.4) mg/dL. Follow-up time was 3.1 (1.3) years, and 112 (47.3%) patients accrued damage during follow-up. In univariable and multivariable analyses, serum uric acid levels were associated with new damage (HR=1.141 (95% CI 1.016 to 1.282), p=0.026; HR=1.189 (95% CI 1.025 to 1.378), p=0.022, respectively).</p></sec><sec><title>Conclusion</title><p>Higher serum uric acid levels are associated with global damage in patients with SLE.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Desideri, G" uniqKey="Desideri G">G Desideri</name></author><author><name sortKey="Castaldo, G" uniqKey="Castaldo G">G Castaldo</name></author><author><name sortKey="Lombardi, A" uniqKey="Lombardi A">A Lombardi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trevi O Becerra, A" uniqKey="Trevi O Becerra A">A Treviño-Becerra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stack, Ag" uniqKey="Stack A">AG Stack</name></author><author><name sortKey="Hanley, A" uniqKey="Hanley A">A 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Ugolini-Lopes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sheikh, M" uniqKey="Sheikh M">M Sheikh</name></author><author><name sortKey="Movassaghi, S" uniqKey="Movassaghi S">S Movassaghi</name></author><author><name sortKey="Khaledi, M" uniqKey="Khaledi M">M Khaledi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castillo Martinez, D" uniqKey="Castillo Martinez D">D Castillo-Martínez</name></author><author><name sortKey="Marroquin Fabian, E" uniqKey="Marroquin Fabian E">E Marroquín-Fabián</name></author><author><name sortKey="Lozada Navarro, Ac" uniqKey="Lozada Navarro A">AC Lozada-Navarro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reategui Sokolova, C" uniqKey="Reategui Sokolova C">C Reátegui-Sokolova</name></author><author><name sortKey="Ugarte Gil, Mf" uniqKey="Ugarte Gil M">MF Ugarte-Gil</name></author><author><name sortKey="Gamboa Cardenas, Rv" uniqKey="Gamboa 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last="Elera-Fitzcarrald">Claudia Elera-Fitzcarrald</name></noRegion><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. Alarc N</name><name sortKey="Alfaro Lozano, Jose" sort="Alfaro Lozano, Jose" uniqKey="Alfaro Lozano J" first="José" last="Alfaro-Lozano">José Alfaro-Lozano</name><name sortKey="Cucho Venegas, Jorge Mariano" sort="Cucho Venegas, Jorge Mariano" uniqKey="Cucho Venegas J" first="Jorge Mariano" last="Cucho-Venegas">Jorge Mariano Cucho-Venegas</name><name sortKey="Elera Fitzcarrald, Claudia" sort="Elera Fitzcarrald, Claudia" uniqKey="Elera Fitzcarrald C" first="Claudia" last="Elera-Fitzcarrald">Claudia Elera-Fitzcarrald</name><name sortKey="Gamboa Cardenas, Rocio Violeta" sort="Gamboa Cardenas, Rocio Violeta" uniqKey="Gamboa Cardenas R" first="Rocio Violeta" last="Gamboa-Cardenas">Rocio Violeta Gamboa-Cardenas</name><name sortKey="Medina, Mariela" sort="Medina, Mariela" uniqKey="Medina M" first="Mariela" last="Medina">Mariela Medina</name><name sortKey="Pastor Asurza, Cesar Augusto" sort="Pastor Asurza, Cesar Augusto" uniqKey="Pastor Asurza C" first="Cesar Augusto" last="Pastor-Asurza">Cesar Augusto Pastor-Asurza</name><name sortKey="Pastor Asurza, Cesar Augusto" sort="Pastor Asurza, Cesar Augusto" uniqKey="Pastor Asurza C" first="Cesar Augusto" last="Pastor-Asurza">Cesar Augusto Pastor-Asurza</name><name sortKey="Perich Campos, Risto Alfredo" sort="Perich Campos, Risto Alfredo" uniqKey="Perich Campos R" first="Risto Alfredo" last="Perich-Campos">Risto Alfredo Perich-Campos</name><name sortKey="Perich Campos, Risto Alfredo" sort="Perich Campos, Risto Alfredo" uniqKey="Perich Campos R" first="Risto Alfredo" last="Perich-Campos">Risto Alfredo Perich-Campos</name><name sortKey="Pimentel Quiroz, Victor Roman" sort="Pimentel Quiroz, Victor Roman" uniqKey="Pimentel Quiroz V" first="Victor Román" last="Pimentel-Quiroz">Victor Román Pimentel-Quiroz</name><name sortKey="Reategui Sokolova, Cristina" sort="Reategui Sokolova, Cristina" uniqKey="Reategui Sokolova C" first="Cristina" last="Reátegui-Sokolova">Cristina Reátegui-Sokolova</name><name sortKey="Reategui Sokolova, Cristina" sort="Reategui Sokolova, Cristina" uniqKey="Reategui Sokolova C" first="Cristina" last="Reátegui-Sokolova">Cristina Reátegui-Sokolova</name><name sortKey="Rodriguez Bellido, Zoila" sort="Rodriguez Bellido, Zoila" uniqKey="Rodriguez Bellido Z" first="Zoila" last="Rodriguez-Bellido">Zoila Rodriguez-Bellido</name><name sortKey="Rodriguez Bellido, Zoila" sort="Rodriguez Bellido, Zoila" uniqKey="Rodriguez Bellido Z" first="Zoila" last="Rodriguez-Bellido">Zoila Rodriguez-Bellido</name><name sortKey="Ugarte Gil, Manuel Francisco" sort="Ugarte Gil, Manuel Francisco" uniqKey="Ugarte Gil M" first="Manuel Francisco" last="Ugarte-Gil">Manuel Francisco Ugarte-Gil</name><name sortKey="Ugarte Gil, Manuel Francisco" sort="Ugarte Gil, Manuel Francisco" uniqKey="Ugarte Gil M" first="Manuel Francisco" last="Ugarte-Gil">Manuel Francisco Ugarte-Gil</name><name sortKey="Zevallos, Francisco" sort="Zevallos, Francisco" uniqKey="Zevallos F" first="Francisco" last="Zevallos">Francisco Zevallos</name></country><country name="États-Unis"><noRegion><name sortKey="Alarc N, Graciela S" sort="Alarc N, Graciela S" uniqKey="Alarc N G" first="Graciela S" last="Alarc N">Graciela S. 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